TH-287 hydrochloride

CAS No. 1638211-05-8

TH-287 hydrochloride ( TH287 hydrochloride )

Catalog No. M12473 CAS No. 1638211-05-8

A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 58 Get Quote
5MG 83 Get Quote
10MG 125 Get Quote
25MG 226 Get Quote
50MG 338 Get Quote
100MG Get Quote Get Quote
200MG Get Quote Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    TH-287 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.
  • Description
    A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
  • Synonyms
    TH287 hydrochloride
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    DNA/RNA Synthesis
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1638211-05-8
  • Formula Weight
    305.59
  • Molecular Formula
    C11H11Cl3N4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N.Cl
  • Chemical Name
    2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.
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