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TH-287 hydrochloride
CAS No. 1638211-05-8
TH-287 hydrochloride( TH287 hydrochloride )
Catalog No. M12473 CAS No. 1638211-05-8
A potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | Get Quote |
|
| 5MG | 83 | Get Quote |
|
| 10MG | 125 | Get Quote |
|
| 25MG | 226 | Get Quote |
|
| 50MG | 338 | Get Quote |
|
| 100MG | Get Quote | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameTH-287 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM.
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DescriptionA potent and selective inhibitor of MTH1 protein with IC50 of 0.8 nM; shows no relevant inhibition for MTH2,NUDT5, NUDT12,NUDT14,NUDT16 and other proteinswith known nucleoside triphosphate pyrophosphatase activity; causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
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In VitroTH287 (1-10 μM; 24 h) selectively and effectively kills U2OS and other cancer cell lines, but is considerably less toxic to several primary or immortalized cells.
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In VivoTH287 (5 mg/kg; i.p.) exhibits Cmax of 0.82 μM and tmax of 0.5 h in mice.
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SynonymsTH287 hydrochloride
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PathwayCell Cycle/DNA Damage
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TargetDNA/RNA Synthesis
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RecptorDNA/RNA Synthesis
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1638211-05-8
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Formula Weight305.5909
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Molecular FormulaC11H11Cl3N4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCNC1=NC(=NC(=C1)C2=C(C(=CC=C2)Cl)Cl)N.Cl
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Chemical Name2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gad H, et al. Nature. 2014 Apr 10;508(7495):215-21.
2. Wang M, et al. Sci Rep. 2017 Jan 11;7:40557.
3. Kawamura T, et al. Sci Rep. 2016 May 23;6:26521.
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